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Medical Management of ICAD:
WASID
Warfarin-Aspirin Symptomatic Intracranial
Disease Trial (WASID)
• Published 2005, NIH funded prospective randomized study; 569
patients enrolled
•
Primary Goal:
to compare warfarin to aspirin for the treatment of
symptomatic intracranial arterial stenosis
– Inclusion criteria: TIA or non-disabling stroke within 90 days of
randomization, 50-99% stenosis, mRS ≤3, ≥40 yrs of age
– Primary endpoint: ischemic stroke, brain hemorrhage, or death
from vascular causes other than stroke
•
Secondary goal:
to identify patients at highest risk of ischemic
stroke in the territory of the symptomatic stenosis, to justify their
inclusion in a subsequent trial of intracranial angioplasty and
stenting
Comparison of Warfarin and Aspirin for Symptomatic Intracranial Arterial Stenosis;
N ENGL J Med
352;13, March 31, 2005.
Presented February 4, 2005, American Stroke Association, New Orleans