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•This Pathway was suggested to
explain the finding of
Osteoporotic bone
•Went beyond a Neurovascular
theory
•Suggests that the OPG/RANKL
pathway is out of synch
because of excess stimulation
of N-f-Kappa-B which is
released due to Cytokine
stimulation TNF and IL-1B
•Suggest that increase in N-F-
kappa B will lead to
osteoclastogenesis
Past Studies: Jeffcoate et al.